Serotonin competence of mouse beta cells during pregnancy
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چکیده
منابع مشابه
the effect of e-64 on the developmental competence of sheep cocs during in vitro maturation
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ALDH Expression Characterizes G1-Phase Proliferating Beta Cells during Pregnancy
High levels of aldehyde dehydrogenase (ALDH) activity have been detected in various progenitor and stem cells. Thus, Aldefluor fluorescence, which represents precisely the ALDH activity, has been widely used for the identification, evaluation, and isolation of stem and progenitor cells. Recently, ALDH activity was detected in embryonic and adult mouse pancreas, specifically in adult centroacina...
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متن کاملSerotonin regulates glucose-stimulated insulin secretion from pancreatic β cells during pregnancy.
In preparation for the metabolic demands of pregnancy, β cells in the maternal pancreatic islets increase both in number and in glucose-stimulated insulin secretion (GSIS) per cell. Mechanisms have been proposed for the increased β cell mass, but not for the increased GSIS. Because serotonin production increases dramatically during pregnancy, we tested whether flux through the ionotropic 5-HT3 ...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2016
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-016-3951-2